Pharma Reference Standard; Pharmaceutical/API Drug Impurities/Metabolites
API
Abacavir
CAS Number
124752-25-6
HS Code
29339900
Molecular formula
C₁₁H₁₄N₆O
Molecular Weight
246.27
Synonyms
Abacavir USP Related Compound A(Abacavir Descyclopropyl impurity)
Appearance
Off-White to Pale Yellow Solid
Melting Point
177°C
Storage
-20°C Freezer
Solubility
DMSO (Slightly), Methanol (Slightly, Heated)
Stability
No Data Available
Boiling Point
No Data Available
Applications
Descyclopropyl Abacavir (Abacavir EP Impurity C; Abacavir Related Compound A) is an intermediate of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Information
This product is for commercial use only and strictly NOT for human or animal consumption
Shipping Condition
Stable to be shipped at room temperature
Inventory Status
In Stock
Quantity
Additonal Comment
Add to Cart
Bulk Enquiry
Chemical Name: Abacavir EP Impurity C
Synonym: Abacavir USP Related Compound A(Abacavir Descyclopropyl impurity)