Product Information

6-Desacetyl-6-Bromo Palbociclib

Catalogue number	PLB-003
Product Name	6-Desacetyl-6-Bromo Palbociclib
Sub Category	Pharma Reference Standard; Pharmaceutical/API Drug Impurities/Metabolites
API	Palbociclib
CAS Number	851067-56-6
Molecular formula	C₂₂H₂₆BrN₇O
Molecular Weight	484.39
Synonyms	6-Bromo-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one; Palbociclib Impurity F
Chemical Name	6-bromo-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one
Appearance	Off-White to Yellow Solid
Melting Point	>105°C (dec.)
Storage	2-8°C Refrigerator
Solubility	Aqueous Acid (Slightly), DMSO (Slightly, Heated), DMF (Slightly, Heated)
Applications	6-Desacetyl-6-Bromo Palbociclib is an impurity of Palbociclib is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.Also, it is derived from 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one, which is used to prepare pyridino[2,3-d]pyrimidin-7(8H)-one derivatives as CDK4 and/or CDK6 inhibitors useful in the treatment of diseases.
Shipping Condition	Ambient
Inventory Status	Under Development
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